Constituent Description

Mendione, Vitamin K3

is a prothrombogenic compound and is used as a model quinone in cell culture and in vivo investigations. 2-Methyl-1,4-naphthoquinone is a synthetic analogue of of 1,4-naphthoquinone with a methyl group in the 2-position. 2-Methyl-1,4-naphthoquinone can be used as an oxidative injury inducing agent.

It is an intermediate in the chemical synthesis of vitamin K by first reduction to the diol menadiol, which is suscepible to coupling to the phytol.

Despite the fact that it can serve as a precursor to various types of vitamin K, menadione is generally not used as a nutritional supplement in economically developed countries. Menadione for human use at pharmaceutical strength is available in some countries with large lower income populations. It is used in the treatment of hypoprothrombinemia outside of the United States.

Menadione in combination with vitamin C has been investigated for the treatment for prostate cancer.[6][7]

A menadione topical lotion reduces epidermal growth factor receptor inhibitor-related side effects by the prevention of skin toxicities that result from inhibition of protein kinases by drugs such as erlotinib (Tarceva) and cetuximab (Erbitux).